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High Specificity in Protein Recognition by Hydrogen-Bond-Surrogate α-Helices: Selective Inhibition of the p53/MDM2 Complex

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Split kit: Synthetic helices target chosen protein–protein interactions with high specificity, as assessed by an in vitro split-protein reassembly assay. By using the p53/MDM2 complex as a model system, both the efficacy of the designed ligands and the suitability of the split-protein assay were determined.

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