Asymmetric Synthesis and Biological Activity of nor-α-Tocopherol, a New Vitamin E Analogue

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Abstract

The vitamin E analogues (2R,4′R,8′R)-nor-α-tocopherol (94 % de) and (2RS,4′R,8′R)-nor-α-tocopherol have been synthesized from (all R)-hexahydrofarnesol and phytol, respectively. According to in vitro experiments with murine macrophages nor-α-tocopherol is an anti-inflammatory compound more potent than α-tocopherol.

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