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Keywords:

  • biosynthesis;
  • genome mining;
  • marine bacteria;
  • proteasome inhibitors;
  • salinosporamides
Thumbnail image of graphical abstract

Evolving biosynthesis: Genome mining of the marine bacterium “Salinispora pacifica” has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.