Communication

Comparison of Staining Selectivity for Subcellular Structures by Carbazole-Based Cyanine Probes in Nonlinear Optical Microscopy

  1. Dr. Mei-Ling Zheng1,2,*,
  2. Dr. Katsumasa Fujita1,*,
  3. Dr. Wei-Qiang Chen2,
  4. Dr. Nicholas Isaac Smith3,
  5. Prof. Xuan-Ming Duan2,
  6. Prof. Satoshi Kawata1

Article first published online: 15 DEC 2010

DOI: 10.1002/cbic.201000593

Issue

ChemBioChem

ChemBioChem

Volume 12, Issue 1, pages 52–55, January 3, 2011

Additional Information

How to Cite

Zheng, M.-L., Fujita, K., Chen, W.-Q., Smith, N. I., Duan, X.-M. and Kawata, S. (2011), Comparison of Staining Selectivity for Subcellular Structures by Carbazole-Based Cyanine Probes in Nonlinear Optical Microscopy. ChemBioChem, 12: 52–55. doi: 10.1002/cbic.201000593

Author Information

  1. 1

    Department of Applied Physics, Osaka University, 2-1Yamadaoka, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-7846

  2. 2

    Laboratory of Organic NanoPhotonics and Key Laboratory of Functional Crystals and Laser Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Zhongguancunbeiyitiao No.2, Beijing 100190 (China)

  3. 3

    Immunology Frontier Research Center, Osaka University, 2-1Yamadaoka, Suita, Osaka 565-0871 (Japan)

*Department of Applied Physics, Osaka University, 2-1Yamadaoka, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-7846

Publication History

  1. Issue published online: 29 DEC 2010
  2. Article first published online: 15 DEC 2010
  3. Manuscript Received: 1 OCT 2010

Funded by

  • NEDO of Japan
  • Knowledge Innovation Program of CAS. Grant Number: KJCX.2.YW.M04
  • National Natural Science Foundation of China. Grant Number: 20702056, 50773091, 50973126
  • ICP. Grant Number: 2008DFA02050, S2010GR0980

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (596K)

Keywords:

  • 3D optical section;
  • cell imaging;
  • fluorescent probes;
  • selective staining;
  • structure–activity relationships
Thumbnail image of graphical abstract

Dyes for living cells: Carbazole-based cyanine probes exhibit excellent properties such as subcellular staining selectivity, large two-photon absorption cross sections, enhanced fluorescence when in their subcellular targets, and low toxicity. They provide a basis for nonlinear high-resolution 3D imaging of subcellular structures, and may have future roles in drug delivery and investigating molecule transport within living cells.

View Full Article with Supporting Information (HTML) Get PDF (596K)