Synthetic Peptidoglycan Motifs for Germination of Bacterial Spores

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Abstract

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Spore cheat: Certain important pathogenic bacteria can produce spores, which are a dormant cell type that is able to resist and survive unfavorable conditions. Environmental factors stimulate the germination of spores and result in regeneration of the bacterium. Minimal bacterial peptidoglycan motifs, prepared herein in multistep syntheses, potently stimulated spore germination in the low-nanomolar range (see scheme).

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