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Keywords:

  • beta-turns;
  • cyclopropylamino acids;
  • NMR spectroscopy;
  • peptidomimetics;
  • prolinoamino acid
Thumbnail image of graphical abstract

Tight turns: Peptide mimics based on combinations of cis-3-prolinoamino acids (prolinohomotryptophan) and (Z)-2,3-methanoamino acids (c3Arg or c3Lys) form stable β-turns in water. This combination of constraints allows one to mimic turns with side chain conformations not accessible with the previously reported strategy involving combinations of prolinoamino acids and N-methylamino acids.