Communication

Flavin-Induced DNA Photooxidation and Charge Movement Probed by Ultrafast Transient Absorption Spectroscopy

  1. Matthias Wenninger1,†,
  2. Danila Fazio2,†,
  3. Uwe Megerle1,
  4. Christian Trindler2,
  5. Stefan Schiesser2,
  6. Prof. Dr. Eberhard Riedle1,
  7. Prof. Dr. Thomas Carell2,*

Article first published online: 18 FEB 2011

DOI: 10.1002/cbic.201000730

Issue

ChemBioChem

ChemBioChem

Volume 12, Issue 5, pages 703–706, March 21, 2011

Additional Information

How to Cite

Wenninger, M., Fazio, D., Megerle, U., Trindler, C., Schiesser, S., Riedle, E. and Carell, T. (2011), Flavin-Induced DNA Photooxidation and Charge Movement Probed by Ultrafast Transient Absorption Spectroscopy. ChemBioChem, 12: 703–706. doi: 10.1002/cbic.201000730

Author Information

  1. 1

    Fakultät für Physik, Lehrstuhl für BioMolekulare Optik, Ludwigs-Maximilians-Universität München, Oettingenstrasse 67, 80538 München (Germany), Fax: (+49) 89-2180-9202

  2. 2

    Department of Chemistry, Ludwigs-Maximilians-Universität München, Butenandtstrasse 5–13, 81377 München (Germany), Fax: (+49) 89-2189-77756

  1. †

    These authors contributed equally to this work.

*Department of Chemistry, Ludwigs-Maximilians-Universität München, Butenandtstrasse 5–13, 81377 München (Germany), Fax: (+49) 89-2189-77756

  1. †

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 15 MAR 2011
  2. Article first published online: 18 FEB 2011
  3. Manuscript Received: 8 DEC 2010

Funded by

  • SFB 749
  • Excellence Cluster NIM (Nano Initiative Munich)
  • GRK 1626 Chemical Photocatalysis

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Keywords:

  • charge transfer;
  • DNA;
  • flavins;
  • oxidative damage;
  • photomutagenesis
Thumbnail image of graphical abstract

Quantum yields of up to 14 % for the formation of a long-lived, charge-separated state can be achieved in flavin-capped DNA hairpins. The excited flavin state is quenched by electron-transfer processes from adjacent DNA bases. The introduction of multiple (dG:dC) base pairs leads to efficient hole trapping that competes with the charge recombination through dA-hopping processes.

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