Small-Molecule Regulators of Human Stem Cell Self-Renewal

Authors

  • Dr. Laure C. Bouchez,

    1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA-92037 (USA), Fax: (+1) 858-784-9440
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  • Dr. Anthony E. Boitano,

    1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA-92037 (USA), Fax: (+1) 858-784-9440
    2. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA-92121 (USA)
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  • Lorenzo de Lichtervelde,

    1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA-92037 (USA), Fax: (+1) 858-784-9440
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  • Russell Romeo,

    1. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA-92121 (USA)
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  • Dr. Michael P. Cooke,

    1. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA-92121 (USA)
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  • Prof. Dr. Peter G. Schultz

    Corresponding author
    1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA-92037 (USA), Fax: (+1) 858-784-9440
    • Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA-92037 (USA), Fax: (+1) 858-784-9440
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Abstract

original image

A cell-based phenotypic screen using primary CD34+ cells identified novel regulators of hematopoietic stem cell (HSC) fate. These compounds expand cord-blood-derived HSCs by acting as potent antagonists of the aryl hydrocarbon receptor.

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