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Keywords:

  • crystal structure;
  • dehydroascorbic acid;
  • nucleic acids;
  • nucleobases;
  • reticulocytes;
  • vitamins
Thumbnail image of graphical abstract

Vitamin C: In addition to being an antioxidant, ascorbic acid in its oxidized form, dehydroascorbic acid (DHA) can alter DNA or RNA function, such as protein biosynthesis upon binding to guanosine. Here we show the EC50 of DHA on different protein systems and X-ray crystal structure of the isolated adduct of dehydroascorbic acid and 9-ethylguanine (see figure).