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Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications

Authors

  • Dr. Abbas Raza,

    1. Center for Drug Design, Academic Health Center, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55455 (USA), Fax: (+1) 612-625-2633
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  • Prof. Robert Vince

    Corresponding author
    1. Center for Drug Design, Academic Health Center, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55455 (USA), Fax: (+1) 612-625-2633
    • Center for Drug Design, Academic Health Center, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55455 (USA), Fax: (+1) 612-625-2633
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Abstract

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Vitamin C: In addition to being an antioxidant, ascorbic acid in its oxidized form, dehydroascorbic acid (DHA) can alter DNA or RNA function, such as protein biosynthesis upon binding to guanosine. Here we show the EC50 of DHA on different protein systems and X-ray crystal structure of the isolated adduct of dehydroascorbic acid and 9-ethylguanine (see figure).

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