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Myricetin: A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity

Authors

  • Alaina S. DeToma,

    1. Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055 (USA), Fax: (+1) 734 615-5521
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    • These authors contributed equally to this work.

  • Dr. Jung-Suk Choi,

    1. Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216 (USA)
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    • These authors contributed equally to this work.

  • Joseph J. Braymer,

    1. Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055 (USA), Fax: (+1) 734 615-5521
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  • Prof. Dr. Mi Hee Lim 

    Corresponding author
    1. Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055 (USA), Fax: (+1) 734 615-5521
    2. Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216 (USA)
    • Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055 (USA), Fax: (+1) 734 615-5521
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Abstract

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Berry good news for the brain: Reactivity of myricetin, a naturally occurring flavonoid (see chemical structure), was investigated in relation to metal-associated amyloid-β (Aβ) species. Myricetin was preferentially effective against metal-associated Aβ over metal-free Aβ species, and was able to modulate metal-induced Aβ aggregation and neurotoxicity in vitro and in human neuroblastoma cells.

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