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Keywords:

  • antibiotics;
  • drug design;
  • oncocin;
  • peptides;
  • structure–activity relationships
Thumbnail image of graphical abstract

Countering MDR pathogens: The proline-rich designer peptide oncocin is highly active against a number of antibiotic-resistant, Gram-negative pathogens. Here we deduce residues critical to its activity and the crystal structure of an oncocin–DnaK complex from a positional Ala scan. New lead compounds were highly resistant against serum and E. coli proteases.