Inside Cover

Inside Cover: Solanapyrone Synthase, a Possible Diels–Alderase and Iterative Type I Polyketide Synthase Encoded in a Biosynthetic Gene Cluster from Alternaria solani (ChemBioChem 9/2010)

  1. Ken Kasahara  Dr.2,4,
  2. Takanori Miyamoto2,
  3. Takashi Fujimoto3,
  4. Hiroki Oguri Dr.3,
  5. Tetsuo Tokiwano  Dr.3,5,
  6. Hideaki Oikawa Prof.3,
  7. Yutaka Ebizuka Prof.2,
  8. Isao Fujii Prof.1

Article first published online: 7 JUN 2010

DOI: 10.1002/cbic.201090038

Issue

ChemBioChem

ChemBioChem

Volume 11, Issue 9, page 1154, June 14, 2010

Additional Information

How to Cite

Kasahara , K., Miyamoto, T., Fujimoto, T., Oguri, H., Tokiwano , T., Oikawa, H., Ebizuka, Y. and Fujii, I. (2010), Inside Cover: Solanapyrone Synthase, a Possible Diels–Alderase and Iterative Type I Polyketide Synthase Encoded in a Biosynthetic Gene Cluster from Alternaria solani (ChemBioChem 9/2010). ChemBioChem, 11: 1154. doi: 10.1002/cbic.201090038

Author Information

  1. 1

    School of Pharmacy, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694 (Japan), Fax: (+81) 19-698-1923

  2. 2

    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)

  3. 3

    Graduate School of Science, Hokkaido University, Kita 10 Nishi 8, Sapporo 060-0810 (Japan)

  4. 4

    Present address: Neo-Morgan Laboratory Inc., Biotechnology Research Center, Teikyo University, 907 Nogawa, Miyamae-ku, Kawasaki, Kanagawa 216-0001 (Japan)

  5. 5

    Present address: Faculty of Bioresource Sciences, Akita Prefectural University, Akita 010-0195 (Japan)

Publication History

  1. Issue published online: 7 JUN 2010
  2. Article first published online: 7 JUN 2010

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Keywords:

  • biological Diels–Alder reaction;
  • biosynthesis;
  • gene sequencing;
  • polyketide synthases;
  • solanapyrone
Thumbnail image of graphical abstract

The inside cover picture shows solanapyrone A biosynthesis by a highly reducing iterative type I polyketide synthase, prosolanapyrone synthase (PSS), and a possible “Diels-Alderase”, solanapyrone synthase (SPS). PSS (top) produces desmethylprosolanapyrone I. In the catalytic cavity of SPS (center), prosolanapyrone II is oxidized to solanapyrone A, possibly by exo-selective Diels–Alder cyclization. For more information, see the paper by I. Fujii et al. on p. 1245 ff.

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