Inside Cover: The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution (ChemBioChem 1/2011)

Authors

  • Dr. Alessandra S. Eustáquio,

    1. Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
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  • Dr. Sang-Jip Nam,

    1. Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
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  • Kevin Penn,

    1. Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
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  • Anna Lechner,

    1. Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
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  • Micheal C. Wilson,

    1. Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
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  • Prof. Dr. William Fenical,

    1. Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
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  • Dr. Paul R. Jensen,

    1. Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
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  • Prof. Dr. Bradley S. Moore

    Corresponding author
    1. Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
    2. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093 (USA)
    • Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305
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Abstract

original image

The inside cover picture showsSalinispora pacifica”. In their Communication on p. 61 ff., B. S. Moore et al. reveal how genome mining of this marine bacterium led to the discovery of salinosporamide K, a new proteasome inhibitor of the salinosporamide structural family. Bioinformatic analysis of its biosynthetic gene cluster revealed a loss of gene function relative to the chlorinated salinosporamide A gene locus of Salinispora tropica that accounts for their structural differences and suggests pathway evolution.

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