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Keywords:

  • actin depolymerization;
  • amphidinolides;
  • cytoskeleton proteins;
  • cytotoxicity;
  • drug discovery
Thumbnail image of graphical abstract

Acting on actin: The mechanism of action of amphidinolide X and amphidinolide J, two relatively small cytotoxic macrolides, has been elucidated. They do not target microtubules and intermediate filaments. The effects observed in A549 and PtK2 cells and the in vitro interaction with actin monomer (G-actin) indicate that these macrolides behave as actin-assembly inhibitors.