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Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J

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This article is corrected by:

  1. Errata: Article first published online:
  2. Errata: Corrigendum: Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J Volume 12, Issue 9, 1293, Article first published online: 9 June 2011

Abstract

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Acting on actin: The mechanism of action of amphidinolide X and amphidinolide J, two relatively small cytotoxic macrolides, has been elucidated. They do not target microtubules and intermediate filaments. The effects observed in A549 and PtK2 cells and the in vitro interaction with actin monomer (G-actin) indicate that these macrolides behave as actin-assembly inhibitors.

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