Identifying Protein Variants with Cross-Reactive Aptamer Arrays

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Abstract

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Sense and sensibility: Synthetic oligonucleotide receptors have been generated that are capable of discriminating proteins with as little as four amino acids substitutions. This leads to the possibility that a panel of cross-reactive aptamers can be an effective tool for discriminating proteins that are structurally similar without the need to generate a unique receptor for each variant.

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