Get access

Design and Synthesis of Selenazole-Containing Peptides for Cocrystallization with P-Glycoprotein

Authors

  • Dr. Houchao Tao,

    1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB265, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-9985
    Search for more papers by this author
  • Yue Weng,

    1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB265, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-9985
    2. Present address: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China)
    Search for more papers by this author
  • Dr. Rupeng Zhuo,

    1. Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 364 14th Street, Lubbock, TX 79430 (USA)
    Search for more papers by this author
  • Prof. Dr. Geoffrey Chang,

    1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB265, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-9985
    Search for more papers by this author
  • Prof. Dr. Ina L. Urbatsch,

    1. Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 364 14th Street, Lubbock, TX 79430 (USA)
    Search for more papers by this author
  • Prof. Dr. Qinghai Zhang

    Corresponding author
    1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB265, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-9985
    • Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB265, La Jolla, CA 92037 (USA), Fax: (+1) 858-784-9985
    Search for more papers by this author

Abstract

original image

Small changes for better X-rays: The synthesis of all 20 natural amino acid-derived selenazole units now makes it possible to create diverse selenium-labeled peptides as X-ray crystallographic tools with which to map the polyspecific binding sites of P-glycoprotein.

Ancillary