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Keywords:

  • aminoglycosides;
  • click chemistry;
  • ribosomal A site;
  • rigid scaffolds;
  • RNA recognition
Thumbnail image of graphical abstract

Exploring RNA recognition: Maximizing affinity for the A site of ribosomal RNA is a task met with a set of spirocyclic compounds that are presented in this work. The chemical syntheses, the biological evaluation and a computational justification of this interesting low-nM fluorescence-based activity are presented.