Communication

Synthesis of 5,6-Spiroethers and Evaluation of their Affinities for the Bacterial A Site

  1. Dr. Ioannis A. Katsoulis,
  2. Dr. Georgia Kythreoti,
  3. Dr. Athanasios Papakyriakou,
  4. Konstantina Koltsida,
  5. Panoula Anastasopoulou,
  6. Dr. Christos I. Stathakis,
  7. Ioannis Mavridis,
  8. Dr. Thomas Cottin,
  9. Emmanuel Saridakis,
  10. Dr. Dionisios Vourloumis*

Article first published online: 6 MAY 2011

DOI: 10.1002/cbic.201100076

Issue

ChemBioChem

ChemBioChem

Volume 12, Issue 8, pages 1188–1192, May 16, 2011

Additional Information

How to Cite

Katsoulis, I. A., Kythreoti, G., Papakyriakou, A., Koltsida, K., Anastasopoulou, P., Stathakis, C. I., Mavridis, I., Cottin, T., Saridakis, E. and Vourloumis, D. (2011), Synthesis of 5,6-Spiroethers and Evaluation of their Affinities for the Bacterial A Site. ChemBioChem, 12: 1188–1192. doi: 10.1002/cbic.201100076

Author Information

  1. Laboratory of Chemical Biology of Natural Products and Designed Molecules, Institute of Physical Chemistry, N.C.S.R “Demokritos”, Agia Paraskevi–Athens, 15310 (Greece), Fax: (+30) 210-651-1776

*Laboratory of Chemical Biology of Natural Products and Designed Molecules, Institute of Physical Chemistry, N.C.S.R “Demokritos”, Agia Paraskevi–Athens, 15310 (Greece), Fax: (+30) 210-651-1776

Publication History

  1. Issue published online: 16 MAY 2011
  2. Article first published online: 6 MAY 2011
  3. Manuscript Received: 1 FEB 2011

Funded by

  • Marie Curie Actions, Excellence Teams (EXT) Grants. Grant Number: MEXT-CT-2006–039 149

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Keywords:

  • aminoglycosides;
  • click chemistry;
  • ribosomal A site;
  • rigid scaffolds;
  • RNA recognition

Graphical Abstract

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Exploring RNA recognition: Maximizing affinity for the A site of ribosomal RNA is a task met with a set of spirocyclic compounds that are presented in this work. The chemical syntheses, the biological evaluation and a computational justification of this interesting low-nM fluorescence-based activity are presented.

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