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Gene Regulation System with an Artificial RNA Switch Operating in Human Cells

Authors

  • Dr. Tamaki Endoh,

    1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Kobe 650-0047 (Japan)
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  • Prof. Dr. Naoki Sugimoto

    Corresponding author
    1. Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Kobe 650-0047 (Japan), Fax: (+81) 78-303-1495
    • Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Kobe 650-0047 (Japan), Fax: (+81) 78-303-1495
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Abstract

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Controlling gene expression: An artificial gene regulation system operating at the transcriptional level in human cells and based on allosteric control of an RNA–protein interaction with the aid of a small ligand has been constructed. This system could be regarded as an artificial RNA switch.

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