SEARCH

SEARCH BY CITATION

Keywords:

  • amino acids;
  • genetic code reprogramming;
  • macrocycles;
  • peptides;
  • ribosomal synthesis;
  • statines
Thumbnail image of graphical abstract

Mine's in the middle: We report here a novel methodology for the ribosomal synthesis of backbone-macrocyclic peptides containing γ-amino acids under the reprogrammed genetic code. Integration of reprogrammed initiation by using exotic dipeptides with C-terminal diketopiperadine-thioester formation has successfully afforded backbone-cyclized peptides with γ-amino acids at an internal position.