Feglymycin is an Inhibitor of the Enzymes MurA and MurC of the Peptidoglycan Biosynthesis Pathway



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Selective inhibition: Feglymycin, a natural 13-mer peptide antibiotic from Streptomyces sp. with activity against MRSA strains was tested in a one-pot assay against the enzymes MurA–F from E. coli. Dereplication revealed that feglymycin specifically inhibits the enzymes MurA and MurC. Feglymycin is therefore the first natural inhibitor of MurC.