These authors contributed equally to this work.
Two Induced Fungal Polyketide Pathways Converge into Antiproliferative Spiroanthrones
Article first published online: 22 JUN 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 12, Issue 12, pages 1836–1839, August 16, 2011
How to Cite
Scherlach, K., Sarkar, A., Schroeckh, V., Dahse, H.-M., Roth, M., Brakhage, A. A., Horn, U. and Hertweck, C. (2011), Two Induced Fungal Polyketide Pathways Converge into Antiproliferative Spiroanthrones. ChemBioChem, 12: 1836–1839. doi: 10.1002/cbic.201100132
- Issue published online: 5 AUG 2011
- Article first published online: 22 JUN 2011
- Manuscript Received: 25 FEB 2011
- Pakt für Wissenschaft und Innovation
- International Leibniz Research School
- Deutscher Akademischer Austauschdienst
- genome mining;
- spiro compounds
Unite in times of deprivation: We report on the use of a chemostat to elicit cryptic biosynthetic pathways in a fungus. Cutlivation of Aspergillus nidulans under N-limiting conditions in a chemostat led to the specific induction of polyketide biosynthesis genes that were otherwise silent. The merger of an anthraquinone with an orsellinic acid-derived oxanthrene yielded two spiroanthrones, sanghaspirodins A and B (see figure).