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Two Induced Fungal Polyketide Pathways Converge into Antiproliferative Spiroanthrones

Authors

  • Dr. Kirstin Scherlach,

    1. Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a, 07745 Jena (Germany)
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    • These authors contributed equally to this work.

  • Anindita Sarkar,

    1. Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena (Germany)
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    • These authors contributed equally to this work.

  • Dr. Volker Schroeckh,

    1. Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena (Germany)
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  • Dr. Hans-Martin Dahse,

    1. Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena (Germany)
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  • Dr. Martin Roth,

    1. Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena (Germany)
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  • Prof. Dr. Axel A. Brakhage,

    1. Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena (Germany)
    2. Friedrich Schiller University, Jena (Germany)
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  • Dr. Uwe Horn,

    1. Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena (Germany)
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  • Prof. Dr. Christian Hertweck

    Corresponding author
    1. Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a, 07745 Jena (Germany)
    2. Friedrich Schiller University, Jena (Germany)
    • Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a, 07745 Jena (Germany)
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Abstract

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Unite in times of deprivation: We report on the use of a chemostat to elicit cryptic biosynthetic pathways in a fungus. Cutlivation of Aspergillus nidulans under N-limiting conditions in a chemostat led to the specific induction of polyketide biosynthesis genes that were otherwise silent. The merger of an anthraquinone with an orsellinic acid-derived oxanthrene yielded two spiroanthrones, sanghaspirodins A and B (see figure).

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