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Keywords:

  • fluorescent probes;
  • hydroxyapatite;
  • molecular imaging;
  • osteocalcin;
  • peptidomimetics
Thumbnail image of graphical abstract

Twinkle, twinkle little bone! A short peptide derived from a natural bone binding protein, osteocalcin, shows excellent selectivity and affinity to hydroxyapatite, the main component of bone. With a fluorescent label, the intravenously injected peptide revealed detailed bone structures in mice, like an X-ray image (see figure).