An MD2 Hot-Spot-Mimicking Peptide that Suppresses TLR4-Mediated Inflammatory Response in vitro and in vivo



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Pain relief in a trunc: A truncated peptide was shown to retain the structure of the TLR4-binding hot-spot region of MD2 and to disrupt TLR4–MD2 interactions. The peptide not only demonstrated strong binding affinity in a fluorescence-polarization assay, but also showed high specificity in macrophages. Furthermore, MD2-I was able to suppress neuropathic pain in animal models.