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Keywords:

  • analgesics;
  • inhibitors;
  • myeloid differentiation factors;
  • peptidomimetics;
  • toll-like receptorsn
Thumbnail image of graphical abstract

Pain relief in a trunc: A truncated peptide was shown to retain the structure of the TLR4-binding hot-spot region of MD2 and to disrupt TLR4–MD2 interactions. The peptide not only demonstrated strong binding affinity in a fluorescence-polarization assay, but also showed high specificity in macrophages. Furthermore, MD2-I was able to suppress neuropathic pain in animal models.