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Keywords:

  • biotechnology;
  • enzyme catalysis;
  • noncanonical amino acids;
  • phosphotriesterase;
  • protein engineering
Thumbnail image of graphical abstract

Teflon-like globular proteins: Global incorporation of p-fluorophenylalanine (pFF) in the S phosphotriesterase dimer (see figure) was found to stabilize the protein and led to refoldability and improved activity for substrates at elevated temperatures.