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Using Modularly Assembled Ligands To Bind RNA Internal Loops Separated by Different Distances

Authors

  • Prof. Dr. Jessica L. Childs-Disney,

    1. Canisius College, Department of Chemistry and Biochemistry, 2001 Main Street, Buffalo, NY 14208 (USA)
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  • Dr. Pavel B. Tsitovich,

    1. Department of Chemistry, University at Buffalo, The State University of New York, Natural Sciences Complex, Buffalo, NY 14260 (USA)
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  • Prof. Dr. Matthew D. Disney

    Corresponding author
    1. Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458 (USA)
    • Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458 (USA)
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Abstract

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Looped in: Modular assembly provides a unique opportunity to tune the affinity and specificity of ligands for a target biomolecule. Herein, we describe our investigations into how the distance between bis-benzimidazole ligand modules (see graphic) affects affinity and specificity for RNA internal loops.

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