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Keywords:

  • bistable DNA;
  • DNA;
  • longitudinal exchange spectroscopy;
  • NMR spectroscopy
Thumbnail image of graphical abstract

Switching of DNA: We address the conformational heterogeneity of DNA on the secondary structure level. While it has been demonstrated that RNA is able to modulate function by changing its folding state, we show for the first time that DNA too can undergo transitions between energetically similar folding states on a time scale that is relevant for biological processes (see figure).