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Hot on the Trail of Trehalose: A Carbohydrate-Based Method for Imaging Mycobacterium tuberculosis

Authors

  • Dennis C. Koester,

    1. Institut für Organische und Biomolekulare Chemie, Georg-August Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)
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  • Shahid I. Awan,

    1. Institut für Organische und Biomolekulare Chemie, Georg-August Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)
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  • Dr. Daniel B. Werz

    Corresponding author
    1. Institut für Organische und Biomolekulare Chemie, Georg-August Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)
    • Institut für Organische und Biomolekulare Chemie, Georg-August Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany)
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Abstract

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Self-denunciation: The trehalose mycolyltransferases have such a broad substrate scope that even fluorescently labelled derivatives are well processed. This can be used to image bacteria such as M. tuberculosis in vitro and in vivo without disturbing either the bacteria's growth or their viability.

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