Get access

Identification of the First Bacterial Monoterpene Cyclase, a 1,8-Cineole Synthase, that Catalyzes the Direct Conversion of Geranyl Diphosphate

Authors

  • Dr. Chiaki Nakano,

    1. Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8567 (Japan)
    Search for more papers by this author
  • Hyo-Kyoung Kim,

    1. Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8567 (Japan)
    Search for more papers by this author
  • Prof. Yasuo Ohnishi

    Corresponding author
    1. Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8567 (Japan)
    • Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8567 (Japan)
    Search for more papers by this author

Abstract

original image

Cycling gear: A sesquiterpene cyclase (SC) homologue, CnsA, from Streptomyces clavuligerus has been identified as a monoterpene cyclase that catalyzes the conversion of GPP into 1,8-cineole (see scheme). This suggests that bacterial SC homologues could include monoterpene cyclases, similar to plant SC homologues.

Ancillary