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A Novel Labda-7,13E-dien-15-ol-Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii

Authors

  • Sibongile Mafu,

    1. Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, 4216 Molecular Biology Building, Ames, IA 50011 (USA)
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  • Dr. Matthew L. Hillwig,

    1. Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, 4216 Molecular Biology Building, Ames, IA 50011 (USA)
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  • Prof. Dr. Reuben J. Peters

    Corresponding author
    1. Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, 4216 Molecular Biology Building, Ames, IA 50011 (USA)
    • Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, 4216 Molecular Biology Building, Ames, IA 50011 (USA)
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Abstract

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Two-in-one enzyme: A bifunctional diterpene synthase from the lycophyte Selaginella moellendorffii has been characterized. The structure of its product, labda-7,13E-dien-15-ol, demonstrates that this enzyme catalyzes a novel class II diterpene cyclization reaction, and clarifies the biosynthetic origins of the family of derived natural products.

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