Hidden in Plain Sight: The Biosynthetic Source of Pyrrolysine Revealed

Authors

  • Dr. Tomasz Fekner,

    1. Department of Chemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA)
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  • Prof. Michael K. Chan

    Corresponding author
    1. Department of Chemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA)
    2. Department of Biochemistry, The Ohio State University, 484 W. 12th Avenue, Columbus, OH 43210 (USA)
    • Department of Chemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA)
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Abstract

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The parsimony of nature: Almost a decade after pyrrolysine was discovered, lysine has been revealed as its sole biosynthetic precursor. En route, the previously claimed involvement of D-ornithine in pyrrolysine biosynthesis has been disproven.

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