Molecular Recognition of Watson–Crick-Like Purine–Purine Base Pairs



original image

Selection of a larger pair: Nucleic acid duplexes with non-Watson–Crick base pairs are of interest to fields that span structural biology, supramolecular chemistry, origin of life, and synthetic biology. Here we demonstrate that intercalating molecules can exhibit selective binding of duplexes with purine–purine base pairs over duplexes with Watson–Crick base pairs, and vice versa.