Nondestructive, Histologically Compatible Tissue Imaging by Desorption Electrospray Ionization Mass Spectrometry

Authors

  • Livia S. Eberlin,

    1. Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47905 (USA)
    Search for more papers by this author
  • Dr. Christina R. Ferreira,

    1. Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47905 (USA)
    Search for more papers by this author
  • Dr. Allison L. Dill,

    1. Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47905 (USA)
    Search for more papers by this author
  • Dr. Demian R. Ifa,

    1. Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47905 (USA)
    Search for more papers by this author
  • Dr. Liang Cheng,

    1. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 (USA)
    Search for more papers by this author
  • Prof. R. Graham Cooks

    Corresponding author
    1. Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47905 (USA)
    • Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47905 (USA)
    Search for more papers by this author

Abstract

original image

Maintaining your integrity: Morphologically friendly DESI-MS imaging of tissue can be performed prior to histochemical and immuno-histochemical analysis on same tissue section by using new solvent systems. This novel DESI-MS imaging capability allows chemical information to be obtained while preserving tissue integrity.

Ancillary