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Keywords:

  • dUVRR;
  • membrane proteins;
  • peptide solvation;
  • Raman spectroscopy;
  • secondary structure
Thumbnail image of graphical abstract

Currently no structurally sensitive spectroscopic techniques are capable of co-determining ensemble structural content and localized lipid versus aqueous solvation information. Here, we describe the first deep-UV (λex<210 nm) resonance Raman (dUVRR) spectra of a model α-helical peptide embedded in a membrane-mimetic environment, confirming sensitivity to secondary structure content and revealing sensitivity of dUVRR to the lipid solvation of the peptide backbone.