Communication

Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides

  1. Ji-Shen Zheng1,2,
  2. Shan Tang2,
  3. Ye Guo2,
  4. Hao-Nan Chang2,
  5. Prof. Dr. Lei Liu1,2,*

Article first published online: 2 FEB 2012

DOI: 10.1002/cbic.201100580

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 4, pages 542–546, March 5, 2012

Additional Information

How to Cite

Zheng, J.-S., Tang, S., Guo, Y., Chang, H.-N. and Liu, L. (2012), Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides. ChemBioChem, 13: 542–546. doi: 10.1002/cbic.201100580

Author Information

  1. 1

    Department of Chemistry, University of Science and Technology of China, Hefei 230026 (P.R. China), Fax: (+86) 10-62771149

  2. 2

    Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China)

*Department of Chemistry, University of Science and Technology of China, Hefei 230026 (P.R. China), Fax: (+86) 10-62771149

Publication History

  1. Issue published online: 29 FEB 2012
  2. Article first published online: 2 FEB 2012
  3. Manuscript Received: 10 SEP 2011

Funded by

  • NSFC. Grant Numbers: 20932006, 91013007
  • Ministry of Science and Technology. Grant Number: 2011CB965300

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Keywords:

  • cyclic peptide;
  • cyclotide;
  • native chemical ligation;
  • peptide hydrazide;
  • solid-phase peptide synthesis
Thumbnail image of graphical abstract

Intramolecular ligation of peptide hydrazides is reported to occur readily, causing the lactamization of fully unprotected peptides in an epimerization-free manner. This method relies on the routine procedures of Fmoc solid-phase peptide synthesis. It can be used to prepare cyclic peptides and cyclic proteins under simpler, mild conditions at lower costs.

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