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Keywords:

  • electrophoresis;
  • label-free kinetics assays;
  • mass spectrometry;
  • proteins;
  • small molecules
Thumbnail image of graphical abstract

Tandem tracker: Here we introduce a method for studying the kinetics of protein–small-molecule interactions based on kinetic capillary electrophoresis (KCE) separation and MS detection. Due to the variety of KCE methods and MS modes available, the KCE-MS tandem is a highly versatile platform for label-free, solution-based kinetic studies of affinity interactions.