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Solubilized Gramicidin A as Potential Systemic Antibiotics

  1. Fang Wang,
  2. Luoheng Qin,
  3. Christopher J. Pace,
  4. Patrick Wong,
  5. Ryan Malonis,
  6. Prof. Jianmin Gao*

Article first published online: 24 NOV 2011

DOI: 10.1002/cbic.201100671

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 1, pages 51–55, January 2, 2012

Additional Information

How to Cite

Wang, F., Qin, L., Pace, C. J., Wong, P., Malonis, R. and Gao, J. (2012), Solubilized Gramicidin A as Potential Systemic Antibiotics. ChemBioChem, 13: 51–55. doi: 10.1002/cbic.201100671

Author Information

  1. Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02461 (USA)

*Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02461 (USA)

Publication History

  1. Issue published online: 22 DEC 2011
  2. Article first published online: 24 NOV 2011
  3. Manuscript Received: 25 OCT 2011

Funded by

  • Boston College
  • NSF. Grant Number: DBI-0619576

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Keywords:

  • antibiotics;
  • drug resistance;
  • gramicidin A;
  • ion channels;
  • transmembrane channels
Thumbnail image of graphical abstract

Makeover of an old antibiotic: The channel-forming toxin gramicidin A (gA) has been successfully converted into agents that selectively chase after bacterial cells. These novel D-Lys-containing gA mutants display potent antimicrobial activity and remarkable therapeutic indexes (>1000-fold).

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