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Keywords:

  • antisense oligonucleotides;
  • DNA decoys;
  • photocaged oligonucleotides;
  • photochemistry;
  • spatiotemporal control
Thumbnail image of graphical abstract

Spot lit: Photocaged nucleic acids have been used to regulate gene expression through the action of light. Whereas most methods target mRNAs, DNA decoys have recently been used to target DNA transcription by targeting specific DNA-transcription-factor interactions. This has allowed researchers to “turn-off” transcription through the action of light on caged nucleic acids for the first time.