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Photocaged DNA Provides New Levels of Transcription Control
Article first published online: 23 JAN 2012
DOI: 10.1002/cbic.201100683
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Ceo, L. M. and Koh, J. T. (2012), Photocaged DNA Provides New Levels of Transcription Control. ChemBioChem, 13: 511–513. doi: 10.1002/cbic.201100683
Publication History
- Issue published online: 29 FEB 2012
- Article first published online: 23 JAN 2012
- Manuscript Received: 31 OCT 2011
Funded by
- National Institutes of Health. Grant Number: DKR0154257
- Abstract
- Article
- References
- Cited By
Keywords:
- antisense oligonucleotides;
- DNA decoys;
- photocaged oligonucleotides;
- photochemistry;
- spatiotemporal control
Spot lit: Photocaged nucleic acids have been used to regulate gene expression through the action of light. Whereas most methods target mRNAs, DNA decoys have recently been used to target DNA transcription by targeting specific DNA-transcription-factor interactions. This has allowed researchers to “turn-off” transcription through the action of light on caged nucleic acids for the first time.