Communication

Insight into the Rescue of Oxidized Soluble Guanylate Cyclase by the Activator Cinaciguat

  1. Dr. Nur Basak Surmeli1,
  2. Prof. Michael A. Marletta1,2,*

Article first published online: 30 MAR 2012

DOI: 10.1002/cbic.201100809

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 7, pages 977–981, May 7, 2012

Additional Information

How to Cite

Surmeli, N. B. and Marletta, M. A. (2012), Insight into the Rescue of Oxidized Soluble Guanylate Cyclase by the Activator Cinaciguat. ChemBioChem, 13: 977–981. doi: 10.1002/cbic.201100809

Author Information

  1. 1

    QB3 Institute, University of California, Berkeley, CA 94720 (USA)

  2. 2

    The Scripps Research Institute, 10550 N. Torrey Pines Road, BCC-555, La Jolla, CA 92037 (USA)

*QB3 Institute, University of California, Berkeley, CA 94720 (USA)

Publication History

  1. Issue published online: 25 APR 2012
  2. Article first published online: 30 MAR 2012
  3. Manuscript Received: 30 DEC 2011

Funded by

  • American Heart Association. Grant Number: 11POST7150020
  • NIH. Grant Number: GM077365

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Keywords:

  • drug design;
  • heme proteins;
  • metalloenzymes;
  • nucleotides;
  • signal transduction
Thumbnail image of graphical abstract

Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme.

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