Inside Cover: Effect of North Bicyclo[3.1.0]hexane 2′-Deoxy-pseudosugars on RNA Interference: A Novel Class of siRNA Modification (ChemBioChem 7/2011)

Authors

  • Dr. Montserrat Terrazas,

    1. Institute for Research in Biomedicine (IRB Barcelona), CIBER-BBN, Institute for Advanced Chemistry of Catalonia (IQAC), Spanish Research Council (CSIC), Cluster Building, Baldiri i Reixac 10, 08028 Barcelona (Spain), Fax: (+34) 932045904
    Search for more papers by this author
  • Dr. Sandra M. Ocampo,

    1. Institute for Research in Biomedicine (IRB Barcelona), CIBER-BBN, Institute for Advanced Chemistry of Catalonia (IQAC), Spanish Research Council (CSIC), Cluster Building, Baldiri i Reixac 10, 08028 Barcelona (Spain), Fax: (+34) 932045904
    Search for more papers by this author
  • Dr. José Carlos Perales,

    1. Department of Ciències Fisiològiques, School of Medicine, University of Barcelona, Campus Bellvitge, C/Feixa Llarga, L'Hospitalet de Llobregat, 08907 Barcelona (Spain)
    Search for more papers by this author
  • Prof. Dr. Victor E. Marquez,

    1. Laboratory of Chemical Biology, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702 (USA)
    Search for more papers by this author
  • Dr. Ramon Eritja

    Corresponding author
    1. Institute for Research in Biomedicine (IRB Barcelona), CIBER-BBN, Institute for Advanced Chemistry of Catalonia (IQAC), Spanish Research Council (CSIC), Cluster Building, Baldiri i Reixac 10, 08028 Barcelona (Spain), Fax: (+34) 932045904
    • Institute for Research in Biomedicine (IRB Barcelona), CIBER-BBN, Institute for Advanced Chemistry of Catalonia (IQAC), Spanish Research Council (CSIC), Cluster Building, Baldiri i Reixac 10, 08028 Barcelona (Spain), Fax: (+34) 932045904
    Search for more papers by this author

Abstract

original image

The inside cover picture shows how siRNAs modified with North bicyclo[3.1.0]hexane 2′-deoxy-pseudosugars are able to activate the RNA interference machinery. The paper confirms that the North conformation is critical for RNAi activity. For further details, see the Full Paper by R. Eritja et al. on p. 1056 ff. Illustration: Montserrat Terrazas.

Ancillary