Cover Picture: Peptide-Functionalized Luminescent Iridium Complexes for Lifetime Imaging of CXCR4 Expression (ChemBioChem 12/2011)

Authors

  • Dr. Joeri Kuil,

    1. Division of Diagnostic Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam (The Netherlands)
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    • These authors contributed equally to this work.

  • Dr. Peter Steunenberg,

    1. Supramolecular Chemistry and Technology, MIRA Institute for Biomedical Chemistry and Technical Medicine, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede (The Netherlands)
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    • These authors contributed equally to this work.

  • Dr. Patrick T. K. Chin,

    1. Netherlands Organization for Applied Scientific Research (TNO), Utrechtseweg 48, 3704 HE Zeist (The Netherlands)
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  • Joppe Oldenburg,

    1. Division of Diagnostic Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam (The Netherlands)
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  • Dr. Kees Jalink,

    1. Division of Cell Biology I, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam (The Netherlands)
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  • Dr. Aldrik H. Velders,

    Corresponding author
    1. Supramolecular Chemistry and Technology, MIRA Institute for Biomedical Chemistry and Technical Medicine, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede (The Netherlands)
    • Supramolecular Chemistry and Technology, MIRA Institute for Biomedical Chemistry and Technical Medicine, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede (The Netherlands)
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  • Dr. Fijs W. B. van Leeuwen

    Corresponding author
    1. Division of Diagnostic Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam (The Netherlands)
    • Division of Diagnostic Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam (The Netherlands)
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Abstract

original image

The cover picture shows a model of a luminescent iridium(III) complex functionalized with three Ac-TZ14011 peptide moieties binding to the chemokine receptor 4 (CXCR4). The G protein-coupled receptor CXCR4 is over-expressed in many types of cancer and, therefore, is a potential biomarker in the field of diagnostic oncology. In the CPK model, the three Ac-TZ14011 peptides are colored by element and the iridium complex is red. The iridium complex has a luminescence lifetime in the order of 200 ns; this enables visualization with fluorescence lifetime imaging microscopy (FLIM). The FLIM image of cells incubated with the peptide–iridium conjugate in the background shows accumulation in the cell membranes; this is in accordance with the membrane location of CXCR4. For further information, see the communication by A. H. Velders, F. W. B. van Leeuwen, et al. on p. 1897 ff.

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