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Keywords:

  • analgesics;
  • inhibitors;
  • myeloid differentiation factors;
  • peptidomimetics;
  • toll-like receptorsn
Thumbnail image of graphical abstract

The inside cover picture shows a rationally designed MD2 hot-spot-mimicking peptide in complex with toll-like receptor 4, which is an important cell-surface receptor that plays critical roles in the innate immune system and in inflammation response. For further details on the binding affinity and specificity of this truncated peptide, see the paper by H. Yin et al. on p. 1827 ff.