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Answers to the Carbon–Phosphorus Lyase Conundrum

  1. Dr. Qi Zhang,
  2. Prof. Dr. Wilfred A. van der Donk*

Article first published online: 14 FEB 2012

DOI: 10.1002/cbic.201200020

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 5, pages 627–629, March 19, 2012

Additional Information

How to Cite

Zhang, Q. and van der Donk, W. A. (2012), Answers to the Carbon–Phosphorus Lyase Conundrum. ChemBioChem, 13: 627–629. doi: 10.1002/cbic.201200020

Author Information

  1. Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, IL 61801 (USA)

*Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, IL 61801 (USA)

Publication History

  1. Issue published online: 15 MAR 2012
  2. Article first published online: 14 FEB 2012
  3. Manuscript Received: 10 JAN 2012

Funded by

  • National Institutes of Health. Grant Number: GM077596

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Keywords:

  • catabolism;
  • enzyme catalysis;
  • lyases;
  • phosphonates;
  • S-adenosylmethionine enzymes
Thumbnail image of graphical abstract

Organophosphonates are widespread in nature, and their catabolic pathways are of great importance for many microorganisms. In a remarkable series of biochemical experiments, Raushel and co-workers reconstituted the carbon–phosphorus lyase activity, which cleaves the C[BOND]P bond of 5-phospho-α-D-ribosyl-methylphosphonate to produce methane and a cyclic phosphodiester in a reaction that requires S-adenosylmethionine and a [4Fe–4S] cluster.

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