Communication

Covalent Tagging of Phosphorylated Peptides by Phosphate-Specific Deoxyribozymes

  1. Dr. Amit Sachdeva,
  2. Dr. Madhavaiah Chandra,
  3. Jagadeeswaran Chandrasekar,
  4. Prof. Scott K. Silverman*

Article first published online: 7 FEB 2012

DOI: 10.1002/cbic.201200048

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 5, pages 654–657, March 19, 2012

Additional Information

How to Cite

Sachdeva, A., Chandra, M., Chandrasekar, J. and Silverman, S. K. (2012), Covalent Tagging of Phosphorylated Peptides by Phosphate-Specific Deoxyribozymes. ChemBioChem, 13: 654–657. doi: 10.1002/cbic.201200048

Author Information

  1. Department of Chemistry, University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, IL 61801 (USA) http://www.scs.illinois.edu/silverman/

*Department of Chemistry, University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, IL 61801 (USA) http://www.scs.illinois.edu/silverman/

Publication History

  1. Issue published online: 15 MAR 2012
  2. Article first published online: 7 FEB 2012
  3. Manuscript Received: 19 JAN 2012

Funded by

  • National Institutes of Health. Grant Number: GM065966
  • Defense Threat Reduction Agency. Grant Number: HDTRA1-09-1-0011
  • National Science Foundation. Grant Number: 0842534
  • NIH. Grant Number: T32 GM070421

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Keywords:

  • deoxyribozymes;
  • DNA;
  • in vitro selection;
  • peptides;
  • phosphopeptides
Thumbnail image of graphical abstract

Hold your P's: Phosphorylated tyrosine and serine residues in peptides have been modified selectively by DNA catalysts (see graphic). These deoxyribozymes catalyze covalent attachment of an RNA tag to a range of peptide sequences, thus a proof of principle for a new approach to phosphopeptide analysis is established.

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