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Keywords:

  • anesthetics;
  • azo compounds;
  • ion channels;
  • neurochemistry;
  • photopharmacology
Thumbnail image of graphical abstract

Light control of voltage-gated ion channels: We have developed red-shifted derivatives of QAQ, a powerful doubly charged photochromic blocker. These derivatives allow for remote control of Kv and Nav channel conductance with light and offer the opportunity to silence neuronal activity reversibly.