Communication

Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers

  1. Timm Fehrentz†,
  2. Christian A. Kuttruff†,
  3. Florian M. E. Huber,
  4. Dr. Michael A. Kienzler,
  5. Dr. Peter Mayer,
  6. Prof. Dr. Dirk Trauner*

Article first published online: 13 JUL 2012

DOI: 10.1002/cbic.201200216

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 12, pages 1746–1749, August 13, 2012

Additional Information

How to Cite

Fehrentz, T., Kuttruff, C. A., Huber, F. M. E., Kienzler, M. A., Mayer, P. and Trauner, D. (2012), Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers. ChemBioChem, 13: 1746–1749. doi: 10.1002/cbic.201200216

Author Information

  1. Department of Chemistry, University of Munich and Center for Integrated Protein Science (CIPSM), Butenandtstrasse 5–13, 81377 Munich (Germany)

  1. †

    These authors contributed equally to this work.

*Department of Chemistry, University of Munich and Center for Integrated Protein Science (CIPSM), Butenandtstrasse 5–13, 81377 Munich (Germany)

  1. †

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 3 AUG 2012
  2. Article first published online: 13 JUL 2012
  3. Manuscript Received: 29 MAR 2012

Funded by

  • Center of Integrated Protein Science, Munich (CIPSM)
  • Deutsche Forschungsgemeinschaft

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Keywords:

  • anesthetics;
  • azo compounds;
  • ion channels;
  • neurochemistry;
  • photopharmacology
Thumbnail image of graphical abstract

Light control of voltage-gated ion channels: We have developed red-shifted derivatives of QAQ, a powerful doubly charged photochromic blocker. These derivatives allow for remote control of Kv and Nav channel conductance with light and offer the opportunity to silence neuronal activity reversibly.

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