Communication

Crystal Structure of a Template-Assembled Synthetic G-Quadruplex

  1. Dr. Mehran Nikan,
  2. Dr. Brian O. Patrick,
  3. Prof. Dr. John C. Sherman*

Article first published online: 24 MAY 2012

DOI: 10.1002/cbic.201200262

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 10, pages 1413–1415, July 9, 2012

Additional Information

How to Cite

Nikan, M., Patrick, B. O. and Sherman, J. C. (2012), Crystal Structure of a Template-Assembled Synthetic G-Quadruplex. ChemBioChem, 13: 1413–1415. doi: 10.1002/cbic.201200262

Author Information

  1. Department of Chemistry, The University of British Columbia, 2036, Main Mall, Vancouver, Canada V6T 1Z1

*Department of Chemistry, The University of British Columbia, 2036, Main Mall, Vancouver, Canada V6T 1Z1

Publication History

  1. Issue published online: 3 JUL 2012
  2. Article first published online: 24 MAY 2012
  3. Manuscript Received: 20 APR 2012

Funded by

  • Natural Sciences and Engineering Research Council of Canada

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (622K)

Keywords:

  • cavitands;
  • crystallography;
  • G-quadruplexes;
  • nucleosides;
  • TASQ
Thumbnail image of graphical abstract

Growing interest in the structure of G-quartets is hampered by the problem of polymorphism. Use of a template to secure the guanines into an organized array can circumvent this problem. We report the first crystal structure of a template-assembled G-quartet. The structure is comparable to those of natural G-quartets, but it also shows quartet–quartet interactions where there is no covalent linkage between the quartets.

View Full Article with Supporting Information (HTML) Get PDF (622K)