Highlight

Moving Pd-Mediated Protein Cross Coupling to Living Systems

  1. Jie Li1,
  2. Prof. Peng R. Chen1,2,*

Article first published online: 4 JUL 2012

DOI: 10.1002/cbic.201200353

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 12, pages 1728–1731, August 13, 2012

Additional Information

How to Cite

Li, J. and Chen, P. R. (2012), Moving Pd-Mediated Protein Cross Coupling to Living Systems. ChemBioChem, 13: 1728–1731. doi: 10.1002/cbic.201200353

Author Information

  1. 1

    Beijing National Laboratory for Molecular Sciences (BNLMS), Department of Chemical Biology, College of Chemistry, and Synthetic and Functional Biomolecules Center, Peking University, Beijing 100871 (P. R. China)

  2. 2

    Peking-Tsinghua Center for Life Sciences, Beijing 100871 (P. R. China)

*Beijing National Laboratory for Molecular Sciences (BNLMS), Department of Chemical Biology, College of Chemistry, and Synthetic and Functional Biomolecules Center, Peking University, Beijing 100871 (P. R. China)

Publication History

  1. Issue published online: 3 AUG 2012
  2. Article first published online: 4 JUL 2012
  3. Manuscript Received: 25 MAY 2012

Funded by

  • National Key Basic Research Foundation of China. Grant Numbers: 2010CB912300, 2012CB917300
  • National Natural Science Foundation of China. Grant Numbers: 91013005, 21001010

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (420K)

Keywords:

  • C[BOND]C bond formation;
  • catalysts;
  • cross coupling;
  • living system;
  • palladium;
  • protein modifications
Thumbnail image of graphical abstract

Palladium goes live: Palladium-mediated carbon–carbon bond formation plays a revolutionary role in advancing organic synthesis. Recently developed biocompatible Pd catalysts have now allowed some of these reactions, such as Suzuki–Miyaura and copper-free Sonogashira cross coupling, to be performed on proteins in living E. coli cells.

View Full Article (HTML) Get PDF (420K)