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Keywords:

  • cytochrome P450;
  • fatty acids;
  • kinetics;
  • oxidation;
  • regioselectivity
Thumbnail image of graphical abstract

The rates of oxidation of fatty acids by CYP119 compound I were dependent on the pH of the medium. The plot shows log k values for reactions of acids as a function of pH, where the slopes indicate mixed third-order and fourth-order dependence on base concentration. For palmitic acid, the rate increased 50-fold over the pH range 6.8–7.3.