Rates of Fatty Acid Oxidations by P450 Compound I are pH Dependent

Authors

  • Dr. Zhi Su,

    1. Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St., Chicago, IL 60607 (USA)
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  • Dr. John H. Horner,

    1. Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St., Chicago, IL 60607 (USA)
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  • Prof. Dr. Martin Newcomb

    Corresponding author
    1. Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St., Chicago, IL 60607 (USA)
    • Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St., Chicago, IL 60607 (USA)
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Abstract

original image

The rates of oxidation of fatty acids by CYP119 compound I were dependent on the pH of the medium. The plot shows log k values for reactions of acids as a function of pH, where the slopes indicate mixed third-order and fourth-order dependence on base concentration. For palmitic acid, the rate increased 50-fold over the pH range 6.8–7.3.

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